My laboratory studies the molecular mechanisms of epigenetic memory, which are key to a number of biological processes, including embryonic development, cancer, stem cell pluripotency, and brain function.
- Molecular mechanisms of epigenetic memory
- Noncoding RNAs
- Chromatin biochemistry
- Genes and behavior
- Laurea (Biotechnology) University Of Milan, 2000.
- PhD (Immunology) Harvard Medical School, 2006.
He C✉, Bozler J, Janssen KA, Wilusz JE, Garcia BA, Schorn AJ, Bonasio R✉. TET2 chemically modifies tRNAs and regulates tRNA fragment levels. Nature Structural & Molecular Biology November 2020.
Sheng L*, Shields EJ*, Gospocic J, Glastad KM, Ratchasanmuang P, Berger SL, Raj A, Little S, Bonasio R. Social reprogramming in ants induces longevity-associated glia remodeling. Science Advances 6(34): eaba9869, August 2020.
Explore the ant brain at single-cell resolution with antSCout.
Yan Q*, Shields EJ*, Bonasio R✉, Sarma K✉. Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach. Cell Reports 29(5): 1369–1380, October 2019.
Zhang Q*, McKenzie NJ*, Warneford-Thomson R*, Gail EH, Flanigan SF, Owen BM, Lauman R, Levina V, Garcia BA, Schittenhelm RB, Bonasio R✉, Davidovich C✉. RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nature Structural & Molecular Biology 26(3): 237-247, March 2019.
Shields EJ, Sheng L, Weiner AK, Garcia BA, Bonasio R. High-quality genome assemblies reveal long non-coding RNAs expressed in ant brains. Cell Reports 23(10): 3078-3090, June 2018.
Download our new ant genome assemblies.
Gospocic J, Shields EJ, Glastad KM, Lin Y, Penick CA, Yan H, Mikheyev AS, Linksvayer TA, Garcia BA, Berger SL, Liebig J, Reinberg D, Bonasio R. The neuropeptide corazonin controls social behavior and caste identity in ants. Cell 170(4): 748-759.e12, Aug 2017.
He C, Sidoli S, Warneford-Thomson R, Tatomer DC, Wilusz JE, Garcia BA, Bonasio R. High-resolution mapping of RNA-binding regions in the nuclear proteome of embryonic stem cells. Molecular Cell 64(2): 416–30, Oct 2016.
Browse the RBR-ID dataset.
Kaneko S, Son J, Shen SS, Reinberg D✉, Bonasio R✉. PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells. Nature Structural and Molecular Biology 20(11): 1258-64, Nov 2013.
Bonasio R*, Zhang G*, Ye C*, Mutti NS*, Fang X*, Qin N*, Donahue G, Yang P, Li Q, Li C, Zhang P, Huang Z, Berger SL✉, Reinberg D✉, Wang J✉, Liebig J✉. Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science 329(5995): 1068-71, Aug 2010.
Bonasio R*, Tu S*, Reinberg D. Molecular signals of epigenetic states. Science 330(6004): 612-6, Oct 2010.
Perelman School of Medicine
University of Pennsylvania
3400 Civic Center Boulevard
Building 421, Philadelphia, PA 19104